Sentence examples for based on existing biological from inspiring English sources

Thus, it is challenging to clearly understand the relationships between the diversity and composition of the observed microbial populations and hydrothermal fluid chemistry based on existing biological and geochemical data for diffusing fluid habitats.

Finally, we investigated gene-gene interaction using a novel bioinformatics approach that restricts the number of pairwise tests based on existing biological knowledge.

Based on these studies, establishing a robust inference regarding the regulatory relationships between a certain transcription factor and its putative target gene(s) could be better accomplished by combining gene expression data with information on transcription factor binding sites and the possible types of interaction based on existing biological knowledge [9].

Here, we present a mathematical model, based on existing biological knowledge and an extensive set of experimental measurements.

Another approach is to select SNPs based on existing biological knowledge (eg, protein protein interactions) and test interactions among them only.

We have now extensively revised and updated the multi-purpose software tool Biofilter that allows researchers to annotate and/or filter data as well as generate gene-gene interaction models based on existing biological knowledge.

The Gene Ontology Consortium is a collection of databases for a variety of organisms, which is commonly used to annotate gene expression based on existing knowledge of biological function and a limited functionally-derived vocabulary.

The crucial task in path analysis is to formulate a plausible path diagram based on existing evidence and current biological concepts.

Modules can be defined in a knowledge-driven fashion based on existing knowledge on pathways, biological processes, and protein complexes [ 5]; they can also be derived in a data-driven fashion by identifying subgroups of genes sharing similar expression pattern across multiple conditions, i.e., co-expression modules [ 7].

We applied TF-Cluster to microarray data from human stem cells and Arabidopsis roots, and then demonstrated that many of the resulting TF clusters contain functionally coordinated TFs that, based on existing literature, accurately represent a biological process of interest.

Likewise, predictions of delta are either based on existing data or are guided by biological plausibility or a minimal clinically important difference (MCID) [ 9, 10].