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Nevertheless, all populations were significantly differentiated based on exact tests.
Sample-size tables are presented for single-stage phase II trials based on exact tests with actual levels of significance and power.
This was congruent with the fact that all populations, except Me Ori-Bwa Meyu and Mt Mou-Ouinee, were significantly differentiated based on exact tests.
For the strong evidence of data presented, the significance level was set based on exact tests, not on the default asymptotic method.
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*Two-sided p-value for Cochran-Armitage test for trend; p-value based on exact test reported for sparse data (any cell < 5).
Sample sizes for single-stage phase II clinical trials in the literature are often based on exact (binomial) tests with levels of significance (alpha <5% and power >80%).
Gene Ontology annotation (http://www.geneontology.org) was used to characterise the functional relevance of each module using functional enrichment approach based on exact Fisher testing and Benjamini and Hochberg multiple testing correction.
Because mid- p tests are based on exact distributions, they are sometimes called quasi-exact [ 14].
For the strong evidence of data presented, the significance level was set based on the exact tests, not on the default asymptotic method.
This paper considers the implications of such approximations in clinical trials in practice and presents sample size for exact α levels based on the exact test.
Based on Fishers exact test the thresholds selected and number of events collected (>100,000/mouse) give chance of false positives as less than 1e-9/mouse.
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