Sentence examples for based on evolutionary information from inspiring English sources
However, due to the limitations of experimental Self-interactions detection, one major challenge in the study of prediction SIPs is how to exploit computational approaches for SIPs detection based on evolutionary information contained protein sequence.
Panther, PhD-SNP and SIFT are based on evolutionary information.
Availability: PconsFold is a fully automated pipeline for ab initio protein structure prediction based on evolutionary information.
The combination of methods based on evolutionary information and protein structure and/or functional parameters were used in order to increase the prediction accuracy.
Thus, we have a vicious circle, where the gene sequences that provide the starting point for most evolutionary analyses are themselves generally predicted based on evolutionary information.
Methods based on evolutionary information for the prediction of mSNPs include SIFT (Ng and Henikoff, 2003) and PolyPhen (Ramensky et al., 2002).
In addition, the B-SIFT algorithm calculates scores of mutation alleles based on evolutionary conservation information [ 3].
SIFT uses a prediction model based primarily on evolutionary information [ 23], whereas PolyPhen-2 adds protein structural data to the feature space [ 24].
MOSST predictions (http://www.biomedcentral.com/1471-2105/12/122/additional, laccessedssed on 19 July 2014) are based on evolutionary and functional information obtained from conservation rules of physicochemical properties of amino acids in a protein family (42).
Here, we present a general framework for inferring such histories and demonstrate how it can be used to determine what interactions existed in the ancestral networks, which present-day interactions we might expect to exist based on evolutionary evidence and what information extant networks contain about the order of ancestral protein duplications.
We also employe the concept of occurrence and composition feature groups to capture global sequence order information based on evolutionary, and structural profiles.
