Sentence examples for based on evolutionary conservation from inspiring English sources
Computational methods are biased toward well-annotated and evolutionarily conserved genomic regions, indeed comparative analyses based on evolutionary conservation alone ignore species-specific functional elements.
Methods based on evolutionary conservation (such as ConCavity and LIGSITEcsc) are biased towards binding sites with biological ligands (meaning ligands that have their biological function i.e 'are supposed to bind there') and therefore can possibly ignore pockets that are not evolutionary conserved but still ligandable with respect to their physico-chemical properties.
Identification of regulatory elements based on evolutionary conservation, also known as phylogenetic footprinting, has the evident drawback of missing regulatory elements responsible for diversity among species.
We next divided all exons into five bins based on evolutionary conservation levels of the exons among 18 placental mammals (see Materials and Methods).
In this note, we used a population genomics approach to reexamine their data and found that the PITA algorithm had lower specificity than methods based on evolutionary conservation at comparable levels of sensitivity.
Of course, neither estimate is congruent with estimates based on evolutionary conservation.
Basing on evolutionary conservation analysis, we also found a significant loss of conserved miRNAs in the Cestoda.
MOSST predictions (http://www.biomedcentral.com/1471-2105/12/122/additional, laccessedssed on 19 July 2014) are based on evolutionary and functional information obtained from conservation rules of physicochemical properties of amino acids in a protein family (42).
Conservation planning based on evolutionary significant units (ESU) has received increasing attention over the last two decades, owing largely to its application under the US Endangered Species Act; there is significant controversy, however, over the relative importance that should be given to genetic distinctiveness versus evolutionary potential (see, e.g. Crandall et al. 2000 and Moritz 2002).
The second is based on Evolutionary Algorithm.
The SIFT algorithm utilizes a sequence homology-based approach to classify amino acid substitutions, which is based on the evolutionary conservation of the amino acids within protein families, while the PolyPhen algorithm uses both sequence- and structure-based prediction.
