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With the purpose of enriched drug-loading and controlled drug release, a lysozyme-actived nanodiamond-methotrexate prodrug (ND-PEG-GLY-MTX, NPGM) was designed based on ester linkage between glycidylated (GLYlated) nanodiamond and methotrexate (MTX).
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We have designed and prepared 40 soft QAC compounds based on both ester and amide linkages, in a systematic study of mono-, bis-, and tris-cationic QAC species.
Based on evidence of linkage, a comprehensive linkage map was developed around this region [ 14].
Clustering in the heat maps is based on average linkage method and Pearson correlation distance metric.
The choice of similarity between groups or items can be measured based on average linkage or nearest neighbour linkage or the farthest neighbour linkage between the points of the groups or ward's method.
It is here that two images can be linked together and judgments based on that linkage can be made.
RAD loci heterozygous in the maternal parent were assigned to linkage groups corresponding to chromosomes, based on complete linkage.
Following their work, Roeder et al. [43] proposed formulating weights based on previous linkage traces.
*For all studies linkage was based on probabilistic linkage.
The covariance structure used in the mixed linear model is based on combined linkage disequilibrium and linkage information.
Then 391 uSNPs were assigned to chromosomes based on their linkage with each of 30 linkage groups.
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