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PRPF31 haplotypes (consecutive series of alleles based on eight SNPs) were associated with risk of invasive disease (p = 0.03).
GRS based on eight SNPs influencing insulin secretion (20) (GRSSECR) also did not have a significant effect (P = 0.459).
Furthermore, GRSSECR based on eight SNPs influencing insulin secretion (at loci KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2B, IGF2BP2, CDKAL1, MTNR1B) (20) was calculated.
Although the haplotypes in Engstrom et al. [ 2011] were based on eight SNPs, the haplotype frequencies were similar when based on the four SNPs included in the present study.
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The CGBN model based on four SNPs (rs9522789, rs7147228, rs2701423, rs759582) and two metabolites monoHETE_0863 and sphingosine-1-phosphate (S1P) could predict asthma control with an AUC of 95%.
In the present study, a Taqman allelic discrimination assay based on three SNPs of the TPI gene is described.
MSL1 gene-level principal components (summarized combinations of genotypes based on two SNPs) were associated with risk of invasive serous disease (p = 0.03).
a Based on the five SNPs; b Based on five SNPs and two risk factors; c Chose as ref. group.
In addition, the AUC of classification based on five SNPs and gender, and based on five SNPs, gender, and age ranged from 0.49 to 0.58, and from 0.50 to 0.59, respectively.
a Based on the five SNPs; b Based on five SNPs and two risk factors; c Adjust for age, age at menarche, menopausal status and age at first live birth where was appropriate.
Subjects are divided into three groups (low, intermediate and high risk) according to their G72 status (based on two SNPs, M23 and M24).
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