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Atomoxetine is usually considered the second line treatment, followed by other non-stimulants like bupropion, guanfacine, modafinil and tricyclic antidepressents, based on efficacy outcomes in controlled studies in different age groups [ 239, 261- 264].
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Furthermore, in a recent prospective study evaluating visual and anatomic outcomes after DEX implant treatment in retinal diseases including DME, the optimal interval for DEX implant retreatment, based on efficacy and safety outcomes, was determined to be 20 weeks (4 to 5 months) [ 23].
Dosage adjustments were allowed based on efficacy and tolerability.
This change in concomitant oral preventive treatment may have had an effect on efficacy outcomes.
Sample size was determined as previously reported and was based on the primary efficacy outcome of treatment failure during the randomized-withdrawal period [ 9].
The evaluation of efficacy was decided to be based on surgical outcomes and secondary and primary clinical outcomes.
It should be noted, further, that success criteria for current efficacy standards are arbitrary and not based on clinical outcomes [ 8, 9].
To demonstrate the efficacy and safety of once-daily nepafenac 0.3% ophthalmic suspension versus vehicle, based on clinical outcomes, after cataract surgery in patients with diabetes.
Since the primary efficacy variable was the most important, the power calculation was based primarily on this outcome; therefore, conclusions based on secondary outcomes should be made with this methodological factor in mind.
Since Proyecto ESCUDO is powered to assess efficacy based on an objective outcome (NSI incidence), results are expected to influence the PEP uptake in the growing number of countries where policing is a key driver of HIV acquisition.
The ranking was based on career outcomes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com