This retrospective study from January 2009 to March 2010 included 16 children treated with lid hygiene plus azithromycin 1.5% eye drops (Azyter®): 3-day treatments (1 drop twice a day) every 10 days, reduced based on efficacy to one treatment every 15 days and then to one treatment per month.
To address this issue, we chose a vector backbone encoding a second-generation CAR based on efficacy of a murine scFv-based CAR.
Future studies will tell whether one agent is superior to the others based on efficacy and side effects.
Here's an idea: how about (a) identifying a problem; (b) suggesting solutions; (c) debating the merits of each solution; (d) researching the cost to the public; and (e) voting based on efficacy, cost-effectiveness and enforcement viability?
Some psychologists have observed that male self-confidence tends to be based on efficacy, how they perform tasks, while female self-confidence tends to be based on self-worth, on more general traits like integrity and compassion.
The 150-mg dose of armodafinil was selected based on efficacy and tolerability data from previous clinical trials.
Most current chemotherapy regimens for cancer consist of empirically designed combinations, based on efficacy and lack of overlapping toxicity.
A group sequential design was chosen to justify early RCT termination based on efficacy or futility at an interim analysis after inclusion of 40 patients.
In addition, the monoclonal antibodies, bevacizumab and cetuximab, have been integrated into recent randomized clinical trial designs, based on efficacy data from advanced disease trials.
1. Perhaps the starkest illustration of this contrast is the "Animal Rule" of the U.S. Federal Drug Administration, which permits drug approval based on efficacy testing on animals rather than humans, "when human efficacy studies are not ethical or feasible" (21 CFR 314.600).
In the previous WHO guidelines, the choice of drugs was based on efficacy and toxicity in a step-down manner, from group 1 first-line drugs and groups 2 5 second-line drugs, to group 5 drugs with potentially limited efficacy or limited clinical evidence.
