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Discounts in Germany are based on early benefit assessment.
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This differential target was originally based on early studies (2, 3), suggesting a benefit from further blood pressure reduction in helping to offset higher renal and cardiovascular risk.
Based on early findings, there may be clinical benefit to adding HA coatings to total knee implants, and most especially to tibial components, where failure of the implant more commonly occurs.
One of the main potential benefits of these tools is the possibility, based on early tumor size measurements collected in phase I and phase II trials, to predict the probable efficacy results of phase III clinical trials.
The use of acetylcholinesterase inhibitors for treating cognitive decline in AD, based on early findings of a cholinergic deficit, has been clinically applied for more than a decade but provides only modest benefits in most patients.
The earliest of these were based on Early Christian models.
Publishers make critical promotional decisions based on early sales.
Based on early definitions of dietary fiber (3), it was thought that non-starch polysaccharides (NSPs) were the most important contributors to the health benefits of fiber while the contribution of resistant starch (RS) was discounted.
Discounted prices negotiated based on the early benefit assessment show that the new system has resulted in substantial rebates within a wide range of results.
Based on earlier research, we estimate that 10-20% of the patients of 65 years or older will benefit from the intensive reactivation program at the PRC (unpublished data).
Drug treatments may be approved based on this marked early benefit, but there may be a poorer justification for continuing use when decreasing benefits are weighed against adverse effects and costs of treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com