Sentence examples for based on driver mutations from inspiring English sources

Molecular classification of lung tumors based on driver mutations represents a major challenge for molecular diagnostics, but also an important opportunity for cancer patients to access to novel drugs.

The starting grid was based on driver points standings.

This is particularly important given that the survival of patients with malignant NETs appears to be different based on the driver mutation(s) present in the tumour and low-grade or intermediate-grade tumours can have a relatively indolent growth.

A current mutation screening program for tailored targeted therapies is also on-going in 1,000 patients with advanced lung adenocarcinoma based on 10 single driver mutations: KRAS (25%), EGFR (23%), ALK rearrangements (6%), BRAF (3%), PIK3CA (3%), MET amplifications (2%), ERBB2 (1%), MEK1 (0.4%), NRAS (0.2%), and AKT1 (<0.1%) [ 30].

This selection should result in driver mutations occurring more frequently in tumor samples; hence, the most common approach for identifying driver mutations is based on calculating mutation frequencies with the assumption that a higher prevalence implies functionality.

Based on the mutations, the researchers think that a common ancestor of the birds lost the enamel caps on its teeth around 116 million years ago.

In the latter step, the statistical confirming procedure, the two lists of possible OGs and TSGs undergo four tests to assess whether the mutational pattern in each gene shows statistically defined evidence of positive selection based on the mutation rate and the number of non-silent mutations, calculating their statistical probability of being true driver mutations.

However, because patients with mutations in familial pancreatic cancer genes, such as those described earlier, are relatively uncommon among patients newly diagnosed with this disease, agents that target pancreatic cancer based on more common somatic driver mutations outlined in Table 2 would be applicable to a greater proportion of patients.

The third GA operator is based on swap mutation.

Although the mutation was heterozygous, he was diagnosed with CTLN2 based on the mutation, recurrent symptoms, hyperammonemia, and hepatic encephalopathy.

Since treatment of cancer does rely on not only the known cancer site, but also the underlying molecular profiles (e.g., cancer driver mutations) and cancer cells migrate to multiple sites at metastasis stage, the prediction of cancer sites based on mutation profiles may be helpful for the enhancement of molecular therapeutics development.