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RCTs were limited and selected based on double blinding, randomization, and placebo control.
As required by the European Medicines Agency and the US Food and Drug Administration for pivotal trials involving allergen immunotherapy (AIT) products, clinical efficacy assessment is currently based on double-blind, placebo-controlled field studies with natural allergen exposure during the allergen season.
Not every medical intervention will be based on double-blind, randomized control trials.
Guidelines on treatment options are primarily based on double-blind RCTs (DBRCTs) [ 6, 7].
RCTs were also very limited and selected based on double-blind, randomized studies with documentation of acne severity.
14 In the 2008 study, all records positive for screening criteria were reviewed by one physician and standardisation of reviews was supported by regular meetings to discuss inter-rater differences based on double-blind reviews in 10% of all records.
Efficacy and tolerability dose response analyses were conducted based on double-blind, placebo-controlled phase II and/or phase III studies including BAP00089, BAP00091 (Part A double-blind retreatment only), BAP01346, and BAP00003.
(Prices are based on double occupancy).
Rates per night based on double occupancy.
Most are based on double occupancy.
Second, we evaluate the validity of this approach based on a double-blind test involving an experimental assemblage of Gutansar obsidian flakes.
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