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Principal component analysis and gene expression-based clustering of compound effects confirmed sample separation based on dose, time, and degree of renal toxicity.
To create a presentation method of TCP and NTCP distributions calculated based on dose distribution for a selected CT slice.
Based on dose, differential scanning calorimetry and dissolution results, a drug/polymer ratio of 40/60 w/w was selected in order to prepare dispersions by melt extrusion.
Trough concentrations were unpredictable based on dose, highlighting the need to follow values during therapy.
A significant response was correctly predicted in 91% of >50 Gy cases (21/23 lesions), based on dose information alone.
The Food and Drug Administration has classified the side effects into groups based on dose levels given every 4 h.
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We employed the P2X7 agonist 3′-O- 4-benzoylbenzoyl) adenosine 5′-triphosphate (BzATP; Sigma-Aldrich) at a concentration of 100 μM, as selected based on dose-response assays.
Although this figure is not really based on dose-finding studies, it has reached the status of a guiding principle.
The maximum-tolerated dose of gandotinib was 120 mg daily, based on dose-limiting toxicities of blood creatinine increase or hyperuricemia at higher doses.
These doses were based on dose-response curves obtained using DR1 mice [12].
These genes are candidates for further testing as markers to classify exposure based on dose-rate.
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