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Prior to haplotype construction, we generated best-guess SNP genotypes based on dosage data and coded expression increasing alleles as '2' and expression decreasing alleles as '1'.
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The most important utilization of an IVIVC is that of predictability of the clinical performance of a dosage form based on dissolution data.
To be within this range, the optimal dosage of EMS based on our data would be an EMS concentration inducing 80% killing.
Furthermore, a population pharmacokinetic model can be used to assist with dosage adjustments by using Bayesian revised dosage predictions based on known concentration time data in each individual 5. Numerous population pharmacokinetic models have been developed to characterize the pharmacokinetics of tacrolimus in adult kidney transplant recipients 6– 16.
Yields of released glucose as a function of the enzyme dosage and residence time were based on experimental data, see Table 6.
Treatment strategies compared in this study were designed based on the data available while complying with drug dosage and administrative recommendations.
The PEI regimen therefore permits greater flexibility in dosage adjustment and treatment delays based on laboratory data or the physical condition of patients.
Examples of carboplatin dosing and exposure in individual patients requiring dosage adjustments based on drug exposure data are shown in Figure 1.
We propose a model, based on our data combined with previous studies cited earlier, which postulates that Pax6 dosage does not affect the rate of corneal epithelial cell migration per se on a neutral substrate.
This study was based on claims data of a major health insurance fund and evaluated the persistence and the dosage increase rates of TNF inhibitors in patients with RA.
Sequential Organ Failure Assessment (SOFA) scores were determined based on local laboratory data, vasopressor dosages, and need for mechanical ventilation.
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