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Prior to haplotype construction, we generated best-guess SNP genotypes based on dosage data and coded expression increasing alleles as '2' and expression decreasing alleles as '1'.
Because M. boninensis is a putative autotetraploid species, we determined the allele copy number of partial heterozygotes based on dosage of electrophoretogram peaks.
The cumulative number of daily doses during the study period was calculated for each person based on dosage, package size and number of packages bought each year.
Thus, in addition to supporting mechanisms based on dosage balance and pleiotropy, our results are also consistent with mechanisms for duplicate gene retention that involve regulatory subfunctionalization.
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We calculated drug costs based on dosages from standard treatment guidelines and information from the International Drug Price Indicator Guide [ 27].
In order to understand the budgetary consequences of such decisions, the estimated cost of diabetes medication should be based on dosages used in real life settings.
The latter should be taken into account when comparing N of SNPs different in frequency between cohorts based on dosages and best-guess.
However, because many current risk assessments are done based on dosages expressed in milligrams per kilogram, rather than milligrams per kilogram body weight3/4, Table 10 and Figure 10 show comparable results for a scenario in which there is constant lifetime exposure in terms of simple milligrams per kilogram body weight.
Dosage for oral administration was based on maximum dosage for daily administration of herbal medicine in traditional herbal medicine clinic.
Thus, by calculating A Ф and AUCФ for attaining the full clinical effect, changes in plasma drug concentration can be obtained, making possible an estimation based on drug, dosage form, and dose.
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