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The four families can be easily distinguished based on domain composition.
We have clustered Fugu CTLDcps using the classification scheme for human CTLDcps based on domain composition; this comprises 14 groups [ 15].
Identified TCS proteins are then classified based on domain composition [ 13], for example the presence of HATPase and HisKA domains leads to classification of a protein as a HK.
Metrics based on domain composition tended to be 'elitist', as the vast majority of TCS genes (~90%) contain only 1 domain, and are therefore of limited usefulness as discriminators.
Although the most important features for ENTS classification are based on domain composition, we also find subcellular localization information from MultiLoc2 to be highly important for prediction of PPIs.
The unrooted phylogenetic tree generated from this alignment supports a recent expansion of the genes that contain the SPRY domain and suggests a preliminary separation of the human TRIM proteins in two main groups based on domain composition and branch topology (Fig. 2).
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Based on domain compositions and sequence similarities, we have classified rice GTs into 41 CAZy families, including one unknown class.
Lastly, we use a consensus Machine Learning approach to predict 379 novel CM genes (coding for 329 proteins) in humans based on domain compositions.
The phylogenetic grouping of the species based on the phylogenetic tree of the coronin domains showed that the coronins with different domain compositions (containing dUTPase domains, ARP2/3 binding domains, no coiled-coil regions) are species-specific developments based on domain loss and gain events while the corresponding species correctly group together inside the respective branches.
Therefore, domain architecture should be designed based on domain requirements.
These TFs were classified into 84 families, including one orphan family, based on their domain composition following the rules for each family given in PlnTFDB.
More suggestions(15)
based on domain versatility
based on domain truncation
based on domain name
based on domain organisation
based on domain search
based on domain family
based on domain scoring
based on domain partitioning
based on domain prediction
based on domain structure
based on domain closure
based on domain discretization
based on domain annotation
based on domain decomposition
based on domain similarity
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