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To evaluate our hypothesis, we developed two new methods that use such information explicitly, one that determines posterior probability of the GO terms based on domain architecture (referred to as the DRDO model), and the other that relies on the naïve Bayes methodology (referred to as the DRDO-NB model).
This family of proteins is broken up into seven distinct subgroups based on domain architecture and their ability to antagonize specific histone methylation marks.
Analysis of their evolutionary relationship revealed that some CP families had evolved according to the phylogeny of the different insect species, while others shared a closer relationship based on domain architecture.
Similar distribution of NCX proteins of all the six species in five clades was found to be strikingly similar (Fig. 2) as in case of Arabidopsis and rice NCXs (Additional file 1: Figure S1), which was found to be based on domain architecture.
PutAs are large, multidomain proteins, and sequence analysis suggests three types of PutA based on domain architecture.
These sequences consist mostly of just a CTLD, and were classified as group VII members based on domain architecture.
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A phylogenetic tree based on domain architectures is produced and regularly updated on the SUPERFAMILY server using PAUP.
In an early attempt, we have tested the use of distance measures based on domain architectures, with moderate success (see Text S1).
Through contextual inference based on domain architectures and predicted operons and structural analysis we present strong evidence that these domains bind small molecules, most probably sugars.
In this study we obtained evidence based on domain architectures and gene neighborhoods that the caspase-like peptidase domains occur both as potential processing peptidases (typically internal domains) and as toxin domains (the C-terminal-most domain) in polymorphic toxins from bacterial lineages such as bacteroidetes, gammaproteobacteria and actinobacteria.
This infrastructure consists of an integrated set of three major components: a controlled terminology service (Enterprise Vocabulary Services), a standards-based metadata repository (the cancer Data Standards Repository) and an information system with an Application Programming Interface (API) based on Domain Model Driven Architecture.
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based on domain composition
based on domain family
based on domain subdivision
based on cascade architecture
based on domain discretization
based on domain structure
based on domain name
based on domain organisation
based on domain ontology
based on domain content
based on network architecture
based on domain truncation
based on microprocessor architecture
based on gene architecture
based on domain mapping
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com