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The limited population size also hindered stratification based on disease duration.
Differences were not seen in PFT changes based on disease duration or based on anti-scl70 status.
To demonstrate this observation graphically, SSc patients were divided into two groups based on disease duration of 2 years.
Although efforts were made to match patient groups based on disease duration, sex, age and other demographic parameters, when such parameters were available, differences in the underlying demographics of the groups could also confound the results.
Although one should note that these efficacy comparisons are not head to head in the same trials, they are consistent with a difference in response based on disease duration.
These data suggest that the circulating cytokine profiles are different in patients based on disease duration, and suggest that alterations in immune balance may change during different stages of SSc.
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Clinical decisions of the treating physicians may assign patients to different drugs based on disease severity, disease duration, presence of comorbidities and other factors.
Clinical decisions of the treating physicians including the final diagnosis of the respective ILD and decisions that may assign patients to different drugs based on disease severity, disease duration, presence of comorbidities, and other factors can potentially introduce allocation or channelling bias and confound the association between treatment and outcomes.
Box-and-whisker plots were used to illustrate the trend in progression of percentage predicted FVC in the overall population and subgroups of patients based on disease type [ 33] and on disease duration at enrollment.
Patients with concomitant diagnoses of chronic bronchitis or emphysema were ineligible; there were no other exclusions based on disease factors such as duration, age of onset, or presence or absence of atopy.
Alpha values for all domains can again be viewed in Table 1.> Construct validity was assessed by comparing domain scores in relation to disease duration (groups split based on median disease duration of 4 years) and gender, as seen in Table 2.
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based on disease state
based on disease outbreak
based on disease etiology
based on cough duration
based on disease label
based on frame duration
based on disease grade
based on treatment duration
based on exercise duration
based on disease co-occurrence
based on pain duration
based on disease presentation
based on poverty duration
based on disease association
based on plating duration
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