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The numbers needed to harm based on discontinuation due to AEs were 8.8 (6.3–14.7) for 120 mg/day duloxetine and 17.5 (10.2–58.8) for 60 mg/day (23).
Patients were categorized as subjects who discontinued (37 [16%]) or subjects who completed (198 [84%]) with lurasidone in the ITT population based on discontinuation due to any cause at the six-week endpoint.
e. Probabilities based on discontinuation rates, regardless of treatment, from data pooled from seven randomised placebo-controlled trials of atomoxetine [ 38- 42] (some are data on file), adjusted for differences between trials with respect to duration of follow-up.
Probabilities based on discontinuation rates due to adverse events from data pooled from six pivotal randomised placebo-controlled trials of atomoxetine [ 38- 42] 42] (some are data on file), adjusted for differences between trials with respect to duration of follow-up.
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The NNH, based on discontinuations from the study, was higher in this trial (16) than in previous trials of 450 mg/day pregabalin in FM patients (in which it ranged from 9 to 11) [ 10, 13, 14], potentially influenced by the somewhat flexible, lower dosing in this study.
The second mechanism is based on a discontinuation of repetitive movements during computer work by physical activity at the workplace.
Dropout was defined based on the discontinuation of program documentation on a particular patient, excluding situations in which the patient died or left the insurance fund.
21, 22 This finding has potential implications for any future economic evaluations of maintenance treatments in PSROC, as it indicates that changes in HSUVs should be modeled based on treatment discontinuation and not radiological progression.
Participants may also be removed from the study based on treatment discontinuation criteria: see box 2. All such cases will be discussed with the trial physician and may result in patient withdrawal from the study, if this is deemed necessary on patient safety grounds.
The annual transition probabilities between the different Markov states were based on rates for total discontinuation, discontinuation due to lack of efficacy (used to determine relapses), and hospitalizations (used to determine relapse-related hospitalizations) from four major data sources (Table 1).
We assume that 40% of patients will discontinue treatment at 12 months based on Australian data on discontinuation of statins [ 21] and blood pressure-lowering drugs [ 22].
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