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Translational medicine facilitates the characterization of disease processes and the generation of novel hypotheses based on direct human observation.
These gene set files are currently the largest set of gene set files publicly available and the only gene sets files where each gene is based on direct human or mouse genetic studies.
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Faced with an explosion in the number of games being released online, the board plans to announce on Monday that the main evaluation of hundreds of games each year will be based not on direct human judgment but instead on a detailed digital questionnaire meant to gauge every subtle nuance of violence, sexuality, profanity, drug use, gambling and bodily function that could possibly offend anyone.
A subset of indels from coding regions was experimentally validated and their impacts were predicted based on direct sequencing in several human populations as well as chimpanzees, bonobos, gorillas, and two subspecies of orangutans.
The human permeability data are based on direct in vivo determinations in the human gastrointestinal tract with a single-pass perfusion system.
We then used orthology to add standardized gene nomenclature and GO annotations (by transferring functional annotations based on direct experimental evidence for corresponding human and mouse orthologs).
Moreover, this iterative search procedure should reduce the effect of fast evolving genomes and differences in the evolutionary rate of the examined species because the ortholog prediction is not merely based on direct ortholog identification starting from human, but predicting orthologs from more closely related species.
Estimates based on direct measurement indicate that in humans and mice individuals express a repertoire of approximately 2 × 107 [ 2] and 2 × 106 [ 3] unique αβTRs respectively.
The precise mechanisms responsible for the high ADCC mediated by fully non-fucosylated therapeutic antibodies, even in the presence of human plasma, should be explained based on direct evidence of non-fucosylated antibody action in human blood.
Predicted mapping of human protein interaction can serve as a surrogate map, years before the complete human protein network based on direct experimental evidence becomes available.
To functionally annotate the predicted proteins we mapped them to the GO annotations for human and mouse orthologs that are based on direct experimental evidence codes (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com