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Our main finding is that only using indicators based on survival may be insufficient, and that indicators based on different outcomes may capture quality differences in different parts of the health status distribution.
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Mann-Whitney-Wilcoxon test 24 and Kendall rank correlation 25 will be performed with statistical software R to determine the agreement among the rankings based on different outcome measures.
Notably, duplications, deletions, inversions and translocations of whole genes would not have been possible without a mechanism to enact them, and there is elegance in the mechanism of homology and recombination that is able to produce quite different outcomes based on different parameters of the situation, and that indeed is also the basis of sexual recombination.
Participants choose strategies and policy goals based on different ideas of what outcomes will best serve their organizational and personal interests.
Currently, most major guidelines focus on 10-year risk estimation, based on different risk algorithms with outcomes including various combinations of fatal and non-fatal events in different arterial territories.
The differences between these methods can be shown to be rather of "degrees of freedom" [21], [45], yet they are based on different assumptions and often yield different outcomes for the same data matrix (as shown in Fig. 4).
I did not use the term "correctly" to describe how assessments (outcomes) are done because what is correct for one set of preferred outcomes based on the underlying student demographics may not be correct for another set of preferred outcomes based on different student demographics.
As the different types of outcome are based on different measurement models and have dissimilar aims, one type of outcome cannot (and should not) be seen as a surrogate for another.
Conflicting results among randomized controlled trials can represent a spectrum of outcomes, based on different patient groups, more than bias or random variability.
Similarly, it would be interesting to examine outcomes based on different therapeutic approaches within and between sites.
Studies evaluating outcomes based on different hemoglobin thresholds for transfusions in a general population of critically ill patients have suggested that keeping hemoglobin level above 10 g/dl offered no benefits when compared with a more conservative target of 7 g/dl [ 23].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com