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Other vaccines based on dendritic cells are being tested in patients, researchers said.
Cancer vaccines based on dendritic cells (DC) are also making progress although clinical efficacy is still lacking.
The ongoing effort to develop melanoma vaccines based on dendritic cells and peptides is driven by advances in understanding antigen presentation and processing, and by new techniques of vaccine preparation, stabilisation and delivery.
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Selection of cells was based on dendritic morphological description of Dcx-positive EF type cells and previously established criteria [45], [46].
Most of the dendritic cell-based vaccinations were based on priming dendritic cells with the specific tumor antigen.
In this study, we designed a metasurface based on dendritic model structures.
Tumour protection after vaccination with vaccines based on DNA, dendritic cells or adenoviruses, is often lost following depletion of CD8+ cells during the effector phase [15], [30] [37].
Despite their potential, antitumor vaccines based on injecting dendritic cells have not been effective.
ECP has been successfully used to treat patients with acute and chronic GVHD in HCT. 13, 18, 30– 32 The mechanism of action of ECP in the setting of GVHD is based on its effect on dendritic cell (DC) integrity and T-cell function.
TNF-α has manifold effects on dendritic cells.
Dendritic cell-specific, intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a C-type lectin expressed specifically on dendritic cells.
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