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A significant pathogenic role for type I interferon (IFN) in lupus pathogenesis was initially suggested in the late 1970's based on demonstrations of increased IFN activity in the blood of lupus patients with active disease (Hooks et al, 1979).
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"The transition will be based on demonstration of capacity rather than a specific time table," the document reads.
Similar guidelines apply to data based on demonstration of the pathogen within a host.
The diagnosis of VL was based on demonstration of leishmania parasites in bone marrow smears.
The diagnosis is based on demonstration of larvae in fresh faeces, which is best made by Baermann technique.
Diagnosis of empyema thoracis was based on demonstration of frank pus upon pleural fluid aspiration prior to admission.
Traditionally, diagnosis is based on demonstration of spirochetes in blood films taken during the acute febrile period.
All four CSL were deemed releasable based on demonstration of normal behavior, absence of abnormal blood values on CBC and serum chemistry, good body condition, and healed incisions.
Confirmation of diagnosis based on demonstration of parasites is necessary (2) during cutaneous leishmaniasis (CL) for definite diagnosis, as CL caused pathology resembles other skin diseases.
This notion was based on demonstration of low ascorbate reserves in cancer patients, and later on results of clinical trials where survival time of cancer patients was prolonged by ascorbate supplementation (Cameron and Pauling 1976, 1978).
Cultivation of this obligate intracellular bacterium is difficult and the diagnosis is therefore based on demonstration of the microbe or microbial DNA in tissue specimens or faecal samples by techniques such as PCR [ 4].
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