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For this purpose, we use three reference models that take into account the degree distribution of the PPI network: (i) reference model based on degree distribution of known disease gene products, (ii) reference model based on the degree of candidate gene products, and (iii) likelihood ratio test using eigenvector centrality as the reference model.
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Sanchirico et al. [10] explored another problem in network theory, namely, characterizing complex networks based on degree distributions.
Based on this degree distribution, the point where the distribution begins to reach its asymptote is detected.
Answer to Minor comments 3: As described in the section "Comparison to Non-Descriptor-Based Methods", we calculated the Kullback-Leibler divergence (KLD) based on the degree distribution between each network.
In contrast to the extrinsic information transfer (EXIT) chart [28], which is based on the degree distribution of LDPC codes, a base matrix is used for the PEXIT chart.
LT codes can generate a limitless number of output symbols from N s input symbols based on a degree distribution { Ω 1, Ω 2, …, Ω N s }, where Ω i is the probability that an output symbol has degree i, and ∑ i = 1 N s Ω i = 1.
Firstly, we investigated the characteristics of miRNAs and diseases in the network based on the degree distribution.
Improved models were those in which the −2 log likelihood ratio was greater than a critical value derived from the chi-square distribution table based on degrees of freedom at an alpha level of 0.05.
GDDA (Przulj, 2007) is based on orbit degree distributions, which are based on the automorphism orbits of the 29 graphlets on 2 5 vertices, as follows.
Classification of the degree of injury is determined based on the distribution of Degree of Injury Value.
In the optimization algorithm, the code C 2 for half-duplex relay network is designed to be rate-compatible with UEP based on the given degree distributions of the UEP capable code C 1. Code C 1 is first designed without the rate-compatible constraint in the optimization algorithm.
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