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The LCI data was interpreted by an impact assessment model based on decision analysis and methods used in life cycle impact assessment.
Modelling studies are based on decision analysis, which is a well-recognised method for analysing the consequences of decisions that are made under uncertainty.
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The RPB is different from Net Benefit (NB) based on decision curve analysis [ 13, 14].
New methods based on decision curve analysis (net benefit) [ 50] and relative utility [ 51] have recently been introduced.
The model built using logistic regression illustrated the highest discrimination metrics (AUC = 0.622, Sens = 0.647, Spec = 0.601), best calibration and the most clinical relevance based on decision curve analysis.
A PC-594 test positivity rate of 5.0% in low-risk reference subjects resulted in a PC sensitivity of 87% and a significant improvement in net clinical benefit based on decision curve analysis.
In this contribution, a quantitative merged process based on multiobjective decision analysis technique- (Promethee), Extended Hazop methodology (Hazop supported by dynamic simulation), reliability modeling and life cycle cost modeling is presented.
This also allows us to determine how many patients in each prognosis group have a risk above the treshold of 17% and how many patients have a risk below the treshold, i.e. for which patients does the use of the treatment treshold based on our decision analysis result in a change in treatment.
The CHEC-list established by Evers et al. is limited to systematic reviews that include full health economic evaluations based on clinical trials; that is, it is not suitable for economic evaluation studies based on decision-analytic modelling or scenario-analysis.
However, a study based on a decision-analysis model applied to eight European countries found that the follow-up costs for the first year after MI (excluding the acute costs of treating the initial event) ranged from €2050 per patient in Portugal to €8631 per patient in Austria (Levy et al. 2003).
To assess data use, we developed dichotomous indicators: discussions of analysis findings, decisions taken based on the analysis, and decisions referred to upper management for action.
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