The use of ADCs represents a promising strategy to overcome the disadvantages of conventional pharmacotherapy of cancer or neurological diseases, based on cytotoxic or immunomodulatory agents.
Further subgroup analysis focused on cytotoxic agents.
γH2AX induction was less apparent and appeared dependent on cytotoxic agent and concentration.
Antimicrobial proteins, including hCAP18/LL-37 hCAP18/LL-37ily been proposed as potential anti-tumour agents based on thave cytotoxic effects at high concentration [ 15, 16].
Our knowledge regarding PK/PD relationships in oncology is based predominantly on cytotoxic and targeted agents that act directly on the tumor cells, whereas CIT acts on cancer immune system interactions.
CPT-11 is preferentially cytotoxic to gastrointestinal (GI) mucosa, and severe diarrhoea is the hallmark toxicity for chemotherapy regimens based on this agent (Gibson et al, 2003; Xue et al, 2007).
The P2Et, S2Et and aqueous fractions were selected for biological testing based on their cytotoxic activity.
Additionally, the combination of an MMP inhibitor with a COX-2 inhibitor may be used with traditional cytotoxic agents, based on promising results observed with such agents used in combination with either a MMP or COX-2 inhibitor (Neri et al, 1998; Fosslien, 2000).
A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration.
(2001), we described a method to estimate relative weights of cytotoxic agents based on a meta-regression analysis of chemotherapy comparing randomised clinical trials.
