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The OPERA suite of prediction models was initially developed based on curated data from the public version of the PHYSPROP database.
Our classifiers were based on curated data from multiple studies and performed well also against the false positive C3 homologs of Ureaplasma, showing accuracy and noise tolerance.
In this article, we introduced a new algorithm to prioritize gene candidates for human genetic disorders based on curated data sets of phenotype annotations.
Specifically, we consider a bipartite multigraph between genes and diseases based on curated data from the reference Online Mendelian Inheritance of Man (OMIM), which tracks published links between diseases and corresponding genes [ 26].
This is expected to enhance data dissemination across resources, as well as analyses based on curated data, thanks to the improved possibilities of filtering data, and of evaluating their trustworthiness.
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This analysis demonstrates that models developed using text-mined MP data from PATENTS provide an excellent prediction performance, similar or even significantly better than the results based on manually curated data used in previous studies.
For this purpose, new classifiers had to be developed which were based on carefully curated data.
GeneGo automatically provides an internal test for association of a given network with a range of annotations, based on manually curated data that is proprietary to GeneGo.
Only recently Dyer and colleagues have described a network between human proteins interacting with viruses and other pathogens based on manually curated data from literature as well as publicly available databases [ 19].
Because no selective purification method exists for the purification and analysis of presynaptic proteins, the criterion for proteins from the presynapse was based on manually curated data mining and confirmed by comparison to proteomic data from whole-synapse (pre plus post) analyses and previously characterized presynaptic subcomplexes in solubilized preparations.
The following SPARQL query identifies a set of 65 molecules that selectively bind Human Cyclin-Dependent Kinase 2 (UniProt: P24941) over Human Cyclin-Dependent Kinase 4 (UniProt: P11802), based on data curated from the literature and stored in the ChEMBL-RDF data model.
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