Mexiletine is currently regarded as the first choice sodium channel blocker based on a recent placebo controlled randomized trial.
Two of the remaining four studies were systematic reviews by the same author but published in different versions of the Cochrane library based on one randomized, controlled trial without any revision.
The best science is based on randomized, controlled experiments that test predictions made by well-developed theoretical models.
This chapter considers the statistical evaluation of vaccine efficacy based on randomized, controlled, preventive vaccine efficacy trials.
Take Head Start which notwithstanding the power of its name and early pilot versions promising great hope for disadvantaged children has consistently been found, in evaluations based on randomized, controlled trials, to provide little or no lasting benefit.
First, findings of this prospective, open-label, uncontrolled, observational study better reflect actual clinical practice conditions than those based on randomized, controlled trials and therefore may be more generalizable to routine ophthalmology practices.
Second, we computed the required sample size (n c ) for a cluster randomized controlled trial based on individually randomized trial sample size using Formula (2), which was developed by Hemming et al. [ 23].
One method was based on a randomized, controlled clinical trial of sodium reduction among men and women followed for 10 to 15 years.
To date, robust evidence on the role of propofol based on large, randomized, controlled trials for this serious condition is still lacking [ 136].
