Sentence examples for based on conserved binding from inspiring English sources
However, computational identification of RNA substrates based on conserved binding motifs is not straightforward because in addition to the sequence context structural features of the RNA are relevant.
Our analysis of potential transcription factors that might be involved in regulating the expression of the identified EC-restricted genes, based on conserved binding sites in the regulatory regions of these genes led to the identification of several classes of transcription factors.
The conserved O. tauri components required for GSK3-mediated S6K regulation are shown in Figure 5, overlaid with the mammalian interactions based on conserved phosphorylation motifs and binding sites.
The phylogenetic reconstruction was based on conserved domains.
Another strategy for cis regulatory modules prediction has been used in the analysis of human and mouse genomes based on finding phylogenetically conserved binding sites for different TFs [ 7, 8].
We next evaluated the contribution of individual binding sites to luciferase signal by making a number of point mutations within conserved binding sites based on already reported cases in the literature.
Degenerate primers were designed based on highly conserved copper-binding regions I and IV of known laccases and used to amplify laccase sequences from T. sanguinea M85-2 genomic DNA.
Domain interactions have also been inferred from protein structure data using information based on geometric association of domain interaction interfaces [17], conserved binding mode analysis from the docking patterns of interacting domains [18], or co-evolutionary analysis [19].
One network was generated from an integration of chromatin immunopurification-on-chip data and conserved binding motifs as described by MacIsaac et al.39.
Me12 and Me15 show limited selectivity against Nav-isoforms, possibly due to the highly conserved binding site on Nav.
5) The Discussion should address what is missed by focusing on only combinatorial binding, only conserved binding, and both.
