During Data Pre-Processing descriptors based on conformational ensembles are computed and stored in a database.
Furthermore, based on conformational changes observed for Uba2 at earlier steps in the Sumo activation cycle, it seems that the Uba2 cysteine domain may also undergo conformational changes to meet the Ubc9 cysteine for Sumo transfer [20].
Cumulating experimental data conflict with mechanisms of disorder-to-order transitions solely based on conformational selection.
In addition, immunoassays based on conformational antibodies have been successfully used to screen DAACPs at the tissue and cellular level.
Therefore, APC differs from AGC, which has a regulatory mechanism based on conformational changes within a dimeric regulatory domain.
Additionally, it is also possible that reduced autoactivation of surface-charged trypsinogen is based on other effects like post-translational modifications, higher stability of the enzyme and/or conformational changes.
The question arises if and how suitable protein conformations can be selected systematically a priori based on quantifiable conformational features.
A novel linker selection strategy based on IB conformational quality and activity was applied to predict the suitable linker.
A colorimetric biosensor for DNA screening was designed based on the conformational changes of the horseradish peroxidase (HRP -mimicking DNAzyme.
Most aptasensors are designed based on aptamers' conformational change or structural transformation upon interaction with their targets.
