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Surface proteins of CGSP14 based on computer prediction are shown in Additional file 7. Several members of the choline-binding protein family are known to be important for virulence, including the autolysin (lytA), choline binding protein A (pspC), and pneumococcal surface protein A (pspA).
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Based on computer predictions this is in agreement with the initiation of translation occurring at nucleotide 22, which demonstrates that the JV N-term protein is translated in full in vitro.
Testing structures that are based on computer predictions with no experimental support creates a bias in the benchmark and will be avoided in this evaluation.
On the other hand, proteins that do have a PTS based on computer predictions may not be peroxisomal because these signals are masked by protein conformation or altered/removed by post-translational processes.
Currently most gene models for the intracellular parasite, Toxoplasma gondii, are based on computer model predictions without cDNA sequence verification.
Based on computer-aided predictions, miRNAs are estimated to target about one third of the human genes (17), so it is not surprising that miRNAs could play a key role in human malignancy.
Based on computer-aided predictions, a single microRNA could have over a hundred of targets.
The prediction, based on computer modeling of published studies, blames warming of the planet's oceans (ScienceNOW, 22 January , 2001.
Comparison of the results from empirical testing of the MABS strategy did not consistently align with prediction based on computer simulations.
But all predictions based on computer projections have inherent uncertainties.
Sceptics highlight the pause as an example of the fallibility of predictions based on computer climate models.
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