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With more and more genomic data available, it will become an inevitable trend to study the complex biological systems based on computational integration of those heterogeneous data.
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Systems pharmacology approaches that simultaneously consider the organism level and the cellular scale will support the development of new drugs by optimizing, for example, risk benefit ratios based on computational models and the integration of targeted physiological information.
An ultraviolet (UV) disinfection reactor based on excimer lamp technology was designed by integration of the results of numerical simulations based on computational fluid dynamics and a fluence rate (E′) distribution model for cylindrical excimer lamps.
Based on computational fluid dynamics (CFD) method, electromagnetic high-frequency method and surrogate model optimization techniques, an integration design method about aerodynamic/stealth has been established for helicopter rotor.
CESA that was predicted to impair protein function based on computational modeling (Slabaugh et al., 2014b).
Based on computational analysis, the missense mutation is predicted to interfere with cytokine to receptor binding.
The above annotation has been implemented based on computational analyses and theoretical prediction.
Therefore, genome-wide identification of miRNA targets is currently based on computational predictive models.
In addition to data from literature, we also include additional information based on computational predictions.
Existing work, based on computational models of phenotype formation, shows that fragmentation is system-dependent.
For proteins not having annotated subcellular information, their subcellular location assignments are based on computational prediction.
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