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The findings of this review are based on comprehensive searching, strict inclusion criteria, and standardized data extraction.
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Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between NRAMP1 polymorphisms and PTB risk.
Based on comprehensive searches of the PubMed, Embase, and Web of Science, we identified outcome data from all articles estimating the association between MS and fracture risk.
This result shows that roles of TFs can be estimated by the principal component analysis (PCA) based on comprehensive searches for functions of gene composing these TUs.
Some systematic reviews are based on comprehensive searches, which aim to have high sensitivity and retrieve references to all relevant papers, whereas others are based on more restricted searches, which may limit the number of relevant papers identified.
Although the Cd-inducible wMT-2 gene of the earthworm Lumbricus rubellus was shown to contain three MREs in the promoter region [21], MTF-1 seems to be absent, a notion which is based on comprehensive experimental and in silico searches [9].
Here we provide our responses to their comments: We agree with the referee (as well as with the other referee) that, although PubMed is a search engine based on comprehensive and authoritative databases, some published papers might not be retrieved by searching in these databases.
"This figure is based on comprehensive analysis undertaken at Aberdeen University.
The diagnosis was based on comprehensive clinical and neuropsychological testing.
Our review is based on a comprehensive search and used rigorous methods for assessing and synthesising the included studies.
This systematic review was based on a comprehensive search strategy using the PRISMA guidelines and included the major databases for medical and educational research.
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