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High ranking MetaCore pathways were "Classic complement pathway", "Lectin Induced complement pathway", and "Alternative complement pathway", based on complement and integrin genes such as C1QA, C1QB, C3, C3AR1, ITGAM, ITGAX, and ITGB2.
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Several urine biomarker tests have been commercialised including NMP22 (nuclear matrix protein 22), BTA TRAK/stat (based on complement factor H) and UBC (cytokeratins 8 and 18) (Tilki et al, 2011), but have not proven sufficiently reliable to gain widespread acceptance.
However, the translation of therapies based on complement inhibition from the bench to bedside has been lacking and more research is required to fully understand the role of complement in the context of clinical IRI and transplantation.
"And this new ecosystem is not based on competition and who is going to win, it's based on complementing each other".
Engineered cell adhesion - based on complementing the EC surface presentation - may be used to increase the strength of EC-matrix interactions.
Other approaches, based on complementing a design optimal for the estimation of the trend parameters with a design optimal for the estimation of the covariance parameters, are under current investigation.
The categorization of individuals as "male" or "female" is based on chromosome complement and gonadal and genital phenotype.
Two different methods that are able to treat complex geometrical configurations are implemented, examined and compared; namely the domain decomposition approach based on Schur's complement and the immersed boundary method.
Table 2 gives the estimates based on the complement of the Kaplan-Meier estimator and the cumulative incidence function, while Table 3 provides estimates based on the ad-hoc estimators.
The projection step is based on the Schur complement and results in a non-linear eigenvalue problem, which is solved exactly.
The beamline controls, are being developed based on EPICS, and complemented with a user-friendly interface.
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