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High ranking MetaCore pathways were "Classic complement pathway", "Lectin Induced complement pathway", and "Alternative complement pathway", based on complement and integrin genes such as C1QA, C1QB, C3, C3AR1, ITGAM, ITGAX, and ITGB2.
However, the translation of therapies based on complement inhibition from the bench to bedside has been lacking and more research is required to fully understand the role of complement in the context of clinical IRI and transplantation.
Several urine biomarker tests have been commercialised including NMP22 (nuclear matrix protein 22), BTA TRAK/stat (based on complement factor H) and UBC (cytokeratins 8 and 18) (Tilki et al, 2011), but have not proven sufficiently reliable to gain widespread acceptance.
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Early, labor-intensive, whole-cell assays based on complement-dependent cytotoxicity suffered from poor sensitivity and specificity, technical challenges and lack of precision.
"And this new ecosystem is not based on competition and who is going to win, it's based on complementing each other".
Engineered cell adhesion - based on complementing the EC surface presentation - may be used to increase the strength of EC-matrix interactions.
Other approaches, based on complementing a design optimal for the estimation of the trend parameters with a design optimal for the estimation of the covariance parameters, are under current investigation.
The most successful and universally recognized deck of cards is that based on a complement of 52, divided into four suits, each containing 13 ranks, so that each card is uniquely identifiable by suit and rank.
Some generalized considerations for the algorithm procedures are given and the problem of LMI set-up, using the technique based on Schur complement, for calculating the terminal weight matrix P is outlined.
DoD's cost-reimbursable contracts (the customer reimburses the supplier for all costs incurred) and profit model (percentage of costs incurred, prenegotiated fee, or increasingly fee plus incentives based on outcome) complement the fixed-price and guaranteed maximum price contracts in industry.
The categorization of individuals as "male" or "female" is based on chromosome complement and gonadal and genital phenotype.
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