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This hypothesis is based on comparative sequence analysis and homology-based structure prediction.
Based on comparative sequence analysis, we designed and evaluated a specific oligonucleotide probe (Pedo 1250) complementary to the hypervariable region 8 of the 16S rRNA gene for Pedomicrobium.
Our current knowledge of genetic differences between FECVs and FIPVs has been mainly based on comparative sequence analyses that revealed "discriminatory" mutations that are present in FIPVs but not in FECVs.
Arachis genomic and transcriptomic resources, both for cultivated tetraploid peanut, Arachis hypogaea L., and its diploid ancestors, Arachis duranensis (A genome) and Arachis ipaënsis (B genome), have been greatly enriched since their status was documented in 2012, leading to an in-depth understanding of genomic architecture based on comparative sequence analyses.
However, by using a related model organism as a proxy for missing functional genomic data and applying multiple layers of subtractive filters based on comparative sequence analysis, we can pre-validate a pool of targets to facilitate their entry into drug discovery programs.
dAssigned based on comparative sequence alignment to mtPhi15-1.
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Both of these methods are based on comparative DNA sequence analysis, but they have significant differences.
Based on comparative 16S rRNA sequence analysis a nested set of new oligonucleotide probes was designed.
These studies are either based on comparative analysis of sequences from different species, or on Mutation and Selection experiments.
1 gi = GenBank gene index number of most homologous sequence obtained by tBLASTx. 2 Based on comparative analysis of similar sequences obtained by tBLASTx with a threshold of 1e-5.
1 gi = GenBank gene index number of most homologous sequence obtained by tBLASTx. 2 Projected function based on comparative analysis of similar sequences obtained by tBLASTx with a threshold of 1e-5.
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