We constructed an ensemble of a few hundred of structural models of the receptor based on comparative homology modeling.
Additional file 16: The protein structure of guanylate binding protein (GBP) 5 appears to be largely conserved between the human, mouse and pig based on comparative protein structure modeling.
To date, several models for the evolution of genomes have been proposed based on comparative genome studies of model organisms [ 45- 47], but little attention has been focused on the structural evolution of duplicated gene families.
It is nevertheless surprising to note that the minimalist model of replication derived using an independent approach based on comparative genomics, resembles the initial model of dual displacement loop mode of replication, suggesting that it prevails at least during advanced developmental stages.
Based on comparative analysis, we developed prediction models using various features like amino acid composition, dipeptide composition and binary profiles.
Two 3D-QSAR models, which based on comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods, were established.
The model derived in our study, using an independent approach based on comparative genomics, surprisingly converges with the dual displacement loop model first put forth by the Kolodner group, based on electron microscopy analyses.
Model fits were evaluated based on Comparative Fit Index (CFI), Tucker Lewis Index (TLI), Root Mean Square Error of Approximation (RMSEA) and Standardized Root Mean Square Residual (SRMR).
This demonstration is based on comparative assessment of those two different sensing solutions (a model of this assessment came from decision support systems domain) [5].
