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For all reported comparisons, the likelihood of Type I error was reduced based on cluster size threshold estimation [27], [28] involving a Monte Carlo simulation calculating the likelihood to obtain different cluster sizes.
Finally, a constraint parameter based on cluster size was used to fine the clusters.
The cluster means of the residuals are then compared in a cluster level analysis using a weighted t-test, with weighting based on cluster size (number of participants per cluster).
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Their key idea is to set multiple compression thresholds adaptively based on cluster sizes at different levels of the data aggregation tree to optimize the amount of data transmitted.
Based on the wcd output, a perl script split the dataset into multiple fasta and associated quality files based on cluster sizes.
For cluster information, users can access the interested gene families based on cluster ID, cluster size and cluster description associated with different MCL inflation values.
The sample size was 1,743 persons based on cluster survey methodology.
This calculation used a two-sided 5% significance level and assumed a design effect of 2 from clustering within practices, based on a cluster size of 100 and an ICC of 0.01.
Final number of clusters was determined to be 16, based on a cluster size of 20 and calcium intake parameters (effect size 250 mg, ICC 0.5 and standard deviation 290 mg) as it required the highest number of clusters.
Based on the cluster size calculation, 10 to 12 hospitals with one or more acute geriatric wards must be recruited.
The design effect was calculated based on a cluster size of 20 and the intracluster correlation coefficient (ICC) using the formula: Design Effect = 1 + (within cluster sample size −1) x ICC.
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