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First, this study is based on clinics instead of population or community.
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Although the comparison groups were based on clinic site, one serving primarily privately insured patients and the other primarily publicly insured patients, there were statistically significant differences between the men at each clinic (i.e., race/ethnicity, recent history of PSA testing, education, and insurance status).
The clinic also provides all physicians with quarterly reports documenting their clinical performance based on clinic and national benchmarks for recommended disease prevention and management.
16 However, at this time current guidelines are based on clinic blood pressure measurements and the study reflects current clinical practice in most countries.
For infrequent testers, a sample size of 14 in each arm will detect an increase in HIV testing frequency from 0.2 tests per year (assuming one HIV test in the past five years based on clinic data [ 73]) to 1 test per year (SD: 0.7) with 80%% statistical power and type I error probability of 0.05.
Adapting the hydrodynamic-based procedure, we established convenient and replication-competent drug-resistant HBV NOD/SCID mice models based on clinic LAM-resistant mutants and evaluated the availability of these models in the assessment of anti-viral drugs.
Particular attention is paid to the generalisability of findings based on clinic-referred boys.
Such lack of dose response relationship between headache and severity of obstructive sleep apnea has previously been reported in two case control studies based on clinic populations from USA and Norway, respectively [16, 28].
Drop-out from the program was calculated based on clinic appointment dates and number of prescribed doses, and a patient was defined as being lost to follow-up if over 90 days had expired since the last prescribed dose.
Where possible, annual follow-up was based on clinic visits.
We did not evaluate incidence of the syndromes based on clinic visitation.
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