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Except of traditionally considered limitations, other reasons may include lack of stratification of analyzed cases based on clinicopathologic parameters, inclusion of patients treated postoperatively by different treatments or neglecting complexity of interactions among tumour constituents.
The Cox model based on clinicopathologic parameters offered substantial prediction power as shown in Figure 1.
The second group (controls) was identified by reviewing all patients treated in the participating medical centers and including patients (diagnosed between 2000 and 2010) for whom treatment decisions were based on clinicopathologic parameters alone and whose baseline characteristics were similar to those in the "Onco type DX" group.
The current study was designed to evaluate the impact of the Recurrence Score results on treatment decisions in N1+ ER+ HER2 negative BC patients and to compare treatment decisions in this patient group with those in a control group comprised of patients in whom treatment decisions were made based on clinicopathologic parameters alone.
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For example, tumour gene expression profiles perform equally well or better than clinicopathologic models, possibly because they reflect a larger component of germline determinants of gene expression in an established tumour than models based on clinicopathologic features11.
Based on clinicopathologic findings, the presence of low papillary structure was significantly associated with lymphatic invasion (P =.023) and lymph node metastasis (P =.001).
We summarize information, based on clinicopathologic studies over the past decade, on various cataract intraocular lens (IOL) procedures and modern "specialized" IOLs, that will help surgeons continuously improve long-term results for cataract patients.
To demonstrate the validity of adaptive optics scanning laser ophthalmoscopy (AOSLO) imaging of the retina in human disease based on clinicopathologic correlation in a patient with cancer-associated retinopathy (CAR).
However, several criteria routinely adopted for the histopathologic diagnosis of MSN are implicitly based on clinicopathologic correlation.
All 52 patients were clearly identified based on clinicopathologic findings.
As described above, NEBCs have typically been reported based on clinicopathologic features [3]– [6].
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