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In January 2011, WHO reported the lack of accuracy of serological tests for TB in HIV populations; 19 however, the present study is the first to assess whether addition of the ICT-TB test result extends the diagnostic value of a screening tool based on clinical predictors in Thailand.
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The added predictive value can then be considered validated if the prediction accuracy of the combined score (i.e., the score involving both the clinical predictors and the omics score) is superior to the prediction accuracy of the clinical score (i.e., the one based only on clinical predictors).
Based on clinical judgment and predictors found to significantly predict mortality in older patients in literature [ 1, 16- 19], we collected the following variables: demographics (age, sex, ethnic group), marital status, housing type, primary diagnosis, co-morbid disease burden and functional status.
Variables selected for inclusion in the models were based on clinical judgment and known predictors derived from the literature.
The ccA/ccB signature was also significant in MVA with the established SSIGN prediction model, demonstrating that this molecular marker can add additional information to one of the best currently available predictors based on clinical and pathologic information.
First, candidate predictors of injuries on CT were combined into dichotomous composite predictors based on clinical similarity and strong biological association (Table 2).
Predictors based on clinical examination within 72 h after CA have demonstrated higher false-positive rates [164].
Predictors based on clinical examination within 72 h after CA have demonstrated higher false-positive rates [ 164].
Candidate predictors were selected based on clinical and statistical grounds (P≤0·25 in univariate analysis).
Construction of the thresholds for each predictor in the MGAP was based on clinical knowledge.
Currently, there are few predictors for the development of these toxicities based on clinical and dosimetric parameters [5] [9].
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CEO of Professional Science Editing for Scientists @ prosciediting.com