Sentence examples for based on clearance of from inspiring English sources

Mean calculated exposures of 1.22 and 1.74 ng OTA kg bw−1, respectively, were derived from this value using either the relationship of dietary exposure = 1.34* Cp (where Cp is plasma concentration) (Hagelberg et al. 1989) based on inulin clearance, or the relationship of dietary exposure = 1.97* Cp (Schlatter et al. 1996) based on clearance of radio-labelled OTA in one person.

In contrast to these findings, hepatic clearance appeared to be normal in Col18a1−/− mice based on clearance of intravenously injected human VLDL (Fig. 2D).

Methods based on clearance of radiolabelled or nonradiolabelled exogenous markers are expensive and not easy to apply in clinical settings.

Our study compared an intensive management strategy with a less-intensive (conventional) management strategy, with intensity defined based on clearance of low molecular weight solutes.

In the present study, we have investigated a novel strategy to correct the hepatic disease of AAT deficiency, based on clearance and prevention of ATZ accumulation by TFEB gene transfer.

The pharmacokinetics of gene drugs after intravenous injection into mice was evaluated based on clearance concepts.

The aims of our study were twofold: first, to test whether the refined PBPK model populated with CYP3A activity change based on oral clearance of MDZ could accurately predict the T3 disposition of other CYP3A-metabolized drugs, namely nifedipine (NIF) and IDV.

Ideally, GFR should be directly measured based on the clearance of infused inulin, iohexol, or radiolabelled tracers.

Therefore, we replaced the third trimester (T3) DEX data with more reliable CYP3A activity data based on oral clearance of the validated probe drug, MDZ.

The interval of 5 days that was applied in the first cohort was selected based on blood clearance studies of TF2 in rabbits (Sharkey et al, 2010), but when it became clear that TF2 cleared relatively rapidly in humans, the interval was reduced to 1 day.

Based on the clearance rate calculations, the clearance model of PQ was developed.