These results support a general model for premature aging in DNA repair deficient mice based on cellular responses to DNA damage that impair normal tissue homeostasis.
54 Moreover, NAb titers have been used as a marker for a protective immune response against flaviviruses, irrespective of whether the actual mechanisms of protection are based on cellular responses, humoral responses, or a combination of both.
The comparison with gold-standard experimental results demonstrates the strengths and weaknesses in relation to prediction based only on cellular response to individual drugs.
Based on cellular and humoral responses, it provides a first line of defense against invading microbes.
It is possible that these cells were already preselected for during the explantation procedure, based on cellular motility, chemotactic responses or plastic adherence characteristics.
However, it is important to caution that these responses likely vary based on cellular context, and although the core target genes and effector dependencies may be conserved, extrapolating this framework to other systems requires careful validation.
In vitro assays based on cellular production of interferon-gamma (IFN-γ) in response to the M. tuberculosis specific antigens ESAT-6 and CFP10 have recently been developed.
Protein GO enrichment based on cellular component.
c Classification of the acetylated proteins based on cellular component.
