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Based on cellular components, the unigenes were classified into six groups, of which all were similarly represented.
GO analysis (based on cellular components, level 2) showed that 5 WSSV proteins and 23 shrimp proteins had GO annotation (Table S2).
Although the GPS is based on estimation of two types of protein – the serum levels of C-reactive protein (CRP) and albumin, which are regulated by inflammatory cytokines – the NLR and thrombocytosis are based on cellular components that are also regulated by such cytokines, especially interleukin-6 (IL-6) (Ohsugi, 2007).
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Protein GO enrichment based on cellular component.
c Classification of the acetylated proteins based on cellular component.
The enrichment analysis based on cellular component showed that proteins distributed in cytoplasm, ribosome, macromolecular complex and non-membrane-bounded organelle have high tendency to be acetylated (Fig. 7a; Additional file 5: Table S4).
These GO annotations are summarized based on cellular component, molecular function and biological process.
The target was selected and categorized based on cellular component, molecular function, and biological process.
The classification based on cellular component revealed that the majority of the proteins are known to be either plasma membrane (34%) or present on the cytoplasm (26%).
(The CMC package comes with its own PPI-cleaning method. However, in order to observe the effect of cleaning based on cellular component GO terms on CMC, this method is not used in this work).
Essentially, the innate invertebrate immune system is based on cellular and molecular components that, upon infection, recognize molecular patterns in the microbial membranes and contribute to the triggering of a cascade of events that culminate with the killing of pathogens.
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