Sentence examples for based on candidate genes from inspiring English sources
Our results highlight the need to identify neuronal signaling networks based on candidate genes, rather than focusing on individual genes and gene products, when attempting to understand the genetic basis of complex behavioral traits.
On the one hand, multiple testing issues arise in most studies, whether based on candidate genes or genomewide scans, with attendant issues of how to quantify the multiplicity, what error rate to control and which method to use [ Manly et al., 2004].
In addition, we are analyzing lipid traits for ∼9000 eMERGE participants based on candidate genes, including LDLR, for single and multiple variant gene-based association discovery work.
Genotyping based on candidate genes oipA and babB was carried out as described [ 24- 26].
Interestingly, no reduction of genetic diversity was observed in the Petkus population based on candidate genes.
The SNP assay was designed based on candidate genes related to disease resistance and Pinus highly conserved genes (HCGs).
Scenario 4 for GENE1 was used to assess the impact of varying the number of anchor markers (either 3, 5 or 7), while for COMT this scenario assessed the impact of how the "anchor" markers were selected: one based on candidate gene study in which SNPs were selected by tagging the region and one based on a priori defined SNPs on a GWAS SNP array.
Interindividual variability in platelet response to agonists and in response to aspirin and clopidogrel administration along with the influence of different single nucleotide polymorphisms on platelet reactivity based on candidate gene and genome-wide association studies have been demonstrated in healthy subjects.
Tag markers are not selected based on "candidate gene variant" considerations [24].
Importantly, genetic heterogeneity is a key feature of retinal degeneration conditions, and to date, over 130 genes with mutations causing one or more forms of inherited orphan retinal degenerative diseases have been cloned, and over 50 more have been identified based on candidate gene studies or linkage mapping (http://www.sph.uth.tmc.edu/retnet).uth.tmc.edu/retnet
