Sentence examples for based on candidate gene from inspiring English sources
Scenario 4 for GENE1 was used to assess the impact of varying the number of anchor markers (either 3, 5 or 7), while for COMT this scenario assessed the impact of how the "anchor" markers were selected: one based on candidate gene study in which SNPs were selected by tagging the region and one based on a priori defined SNPs on a GWAS SNP array.
Tag markers are not selected based on "candidate gene variant" considerations [24].
Importantly, genetic heterogeneity is a key feature of retinal degeneration conditions, and to date, over 130 genes with mutations causing one or more forms of inherited orphan retinal degenerative diseases have been cloned, and over 50 more have been identified based on candidate gene studies or linkage mapping (http://www.sph.uth.tmc.edu/retnet).uth.tmc.edu/retnet
This paper reports the identification of resistance QTL for SHR based on candidate gene AM.
This article reports the identification of QTL for resistance to SHR based on candidate gene AM.
However, the survey was based on candidate gene studies, which might have biased upward the reuse estimates.
Our results highlight the need to identify neuronal signaling networks based on candidate genes, rather than focusing on individual genes and gene products, when attempting to understand the genetic basis of complex behavioral traits.
On the one hand, multiple testing issues arise in most studies, whether based on candidate genes or genomewide scans, with attendant issues of how to quantify the multiplicity, what error rate to control and which method to use [ Manly et al., 2004].
In addition, we are analyzing lipid traits for ∼9000 eMERGE participants based on candidate genes, including LDLR, for single and multiple variant gene-based association discovery work.
