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The high proportion of patients requiring changes to their treatment regimen, based on both drug resistance and adverse events, suggests that close monitoring and frequent assessment of sputum culture and drug resistance where patients remain or become sputum culture-positive during treatment is essential.
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Moreover, these types of models can detect drug pair similarities based on whether both drugs are in the same or different pharmacological classes.
Therapeutic strategies are mainly based on both preventive and abortive drug therapy.
More generally, this report, together with others suggest that precision medicine may be better based on both genomic data and drug response (including ex vivo) data than on only one of these.
Major strengths of this study are the investigation of multiple outcome measures, several commonly-used general measures of comorbidity and measures based on both diagnosis and prescription drug codes.
†Diagnoses based on both hospital discharge diagnoses and drug prescriptions.
The anti-wasting effects of the drug were based on both an activation of the rate of protein synthesis and an inhibition of the rate of muscle proteolysis.
Based on both logistic regression analyses, where predicted drug concentrations can estimate the probability of adverse events, and the tolerability of temsirolimus over a wide dose range, the likelihood of severe toxicity occurring from this type of drug interaction is thought to be low with the 25-mg dose.
Ideally, these calculations would be based on drug exposure rather than drug acquisition.
We propose to update that analysis, and hypothesize, based on recent drug developments in both diabetes management and treatment of depression, that individuals with both diabetes and minor depression will have higher rates of health care utilization in four categories: ambulatory care, inpatient care, emergency department visits, and prescription medications.
Combination therapy uses several antivirus drugs with different mechanisms of action in one regime to achieve greater efficacy than one drug dose alone based on drug synergistic effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com