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Previous approaches based on bone biopsy and discectomy exhibit important methodological limitations.
Heightened vigilance is needed for CA-MRSA osteomyelitis of long bones in adults as it is not uncommon for this disease to mimic primary bone malignancy, which can be ruled out based on bone biopsy supported by microbiological evidence.
In addition to clinical signs and symptoms the diagnosis of osteomyelitis was based on bone biopsy and MRI in 11 patients (2 had a negative culture but were positive on histology), on MRI alone in 24 patients and on bone scan alone in 2 patients (MRI and/or bone biopsy not assessed).
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Secondary objectives were to compare response rates, including CR and CRp, based on bone marrow biopsies and aspirates.
Patients are initially treated empirically with broad-spectrum antimicrobials, changed to targeted antimicrobial therapy based on bone culture results of samples taken at debridement surgery or from deep bone biopsies.
Post-DFO serum Al level > 3.0 μmol/L was defined to indicate toxic loads based on previous bone biopsy studies.
Chapter VII on parathyroidectomy in chronic kidney disease is presented, with appendix 2 on bone biopsy.
They also have mesh-like lamellation on bone biopsy as well as a mineralization defect.
Five among seven patients with malignancy had lymphoid malignant disorder (LMD) based on biopsy from bone marrow, skin or lymph node, and among these one patient died who had spleen abscess as an infectious aetiological diagnosis of fever.
In univariate regression analysis, %PABS (P=0.0155), serum alkaline phosphatase (P=0.0272), the tumour grade based on biopsy (P=0.044) and the number of bone lesions on bone scans (P=0.0388) were significantly associated with the disease-specific survival.
The diagnosis of amyloidosis was based on kidney biopsy in five patients, on colonic biopsy in one patient, and on labial biopsy in one patient.
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