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The estimated exposure level of TCS based on biomonitoring data is much higher than the product-based TCS intake estimates and suggests that actual TCS intakes are lower than the product-based estimates.
Estimates of DEP exposure in the general population, based on biomonitoring data, are 5.4 μg/kg/day, with a 95th percentile of 64.7 μg/kg/day (Table 4).
One approach is based on the estimation of the combination of daily intake products, and the other is based on biomonitoring data from human volunteers.
Assessments of exposure (David 2000; Kohn et al. 2000) indicate that the exposures based on biomonitoring data are substantially less than either NOAEL.
However, the research conducted during the last decade indicates many uncertainty factors in methods of exposure assessment, both when estimating exposure using data on environmental analyses and behaviours, and when the assessment is based on biomonitoring data [ 12].
The reverse dosimetry problem, however, is a problem of statistical inference: we wish to determine an estimate of exposure for the general population based on biomonitoring data collected from a representative sample of that population.
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In addition to the studies based on biomonitoring of exposure, two were based on dietary Cd exposure, combining individual food consumption data from a food-frequency questionnaire with data on Cd content in food (Engström et al. 2012; Thomas et al. 2011).
However, the US FDA, EFSA, and the Japanese government have evaluated the available biomonitoring studies and concluded that the exposure estimates based on food concentrations and migration of BPA are conservative compared to daily intakes based on biomonitoring.
Although exposure estimates based on the biomonitoring data are similar to those derived from food consumption, it should be noted that the biomonitoring data were derived from a subset of the general population and that population sampling did not account for dietary or other lifestyle factors that could influence methyl eugenol serum levels.
Based on the biomonitoring data available for PFOS and PBDEs in the United States, the range of biologic values in the general population is quite large, and the data are log-normally distributed (Birnbaum and Cohen Hubal 2006; Butenhoff et al. 2006).
To allow for a common metric across disparate activities, we used liter--equivalents based on human biomonitoring data collected during controlled dermal or inhalation studies of TCM (Kerger et al. 2000; Weisel and Jo 1996) and previously applied in epidemiological studies (Dodds et al. 2004; King et al. 2004).
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