Based on bioisosteric and scaffold hopping principle, two dabigatran mimics (I-1 and II-1) in which the benzamidine moiety of dabigatran was replaced by a tricyclic fused scaffold were designed, synthesized and evaluated for their in vitro activities for inhibiting thrombin.
Based on bioisosteric similarities with isoniazid, a series of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives has been designed.
Twenty-one fluorinated dabigatran derivatives were designed based on the bioisosteric principle.
Based on the bioisosteric principle, novel series of 1,2,3-selenadiazole thioacetanilide derivatives were designed, and synthesized using an original synthetic route, structurally confirmed by spectral analysis, and evaluated for their anti-HIV activity in MT-4 cells.
Based on the bioisosteric principle, a novel series of 2- 2- 2,4-dichlorophenyl -2H-1,2,4-triazol-3-ylthio -N-arylacetamide derivatives were designed, synthesized using a simple and efficient synthetic route, structurally confirmed by spectral analysis, evaluated for their anti-HIV activity in MT-4 cells and their inhibitory effect on HIV-1 RT.
Successful gardens are almost always based on a unifying principle or principles.
Their constitution was based on three principles.
A moral system based on universal principles.
