Sentence examples for based on binding site from inspiring English sources
As for C/EBP isoforms, it is not possible to identify any specific ATF component candidate based on binding site information alone, since all members of the ATF family bind to the same consensus DNA sequence (TGACGTCA).
We herewith present a computational method based on binding site three-dimensional comparisons, which prompted us to investigate the cross-reaction of protein kinase inhibitors with synapsin I, an ATP-binding protein regulating neurotransmitter release in the synapse.
It is important to note that these networks are based on direct experimental measurements, and not on putative interactions based on binding site predictions.
A total of 1397 unique regulator-target gene relationships (corresponding to 2056 predicted binding sites) based on binding site data alone corresponding to 44 S.
We develop a new method, Regulus, which computes a probabilistic score of similarity based on binding site composition (despite the absence of nucleotide-level sequence alignment), and demonstrate similarity between functionally related CRMs from orthologous loci.
The chemosensor L successfully detect Cu2+, Hg2+ and Ag+ based on binding site-signalling approach, where the thiourea group acts as binding site and the pyridine linked benzene ring acts as signalling unit.
Peptides were short chains of amino acids that can be designed based on binding sites of proteins, screened into specific sequences, and finally synthesized with chemical methods.
Potential MBS in BCL2 promoters 1 and 2 were identified based on binding sites previously mapped in other cell types [ 34, 35] in conjunction with the established consensus sequence YAACN(G/T) for MYB protein binding [ 36, 37].
The global regulators CcpA (catabolite repressor protein) and CodY (global regulator of amino acid metabolism) together accounted for ~29.22% of the 2445 regulator-target gene relationships based on binding sites.
They constructed a set of five position frequency matrices based on binding sites for MEF2, Myf, SRF, TEF-1 and Sp1 transcription factors which were found to bind within these sequences.
The default values maximize the average area under the Receiver-Operator Characteristic (ROC) curve (AUC) in predictions of ligand-binding classes based on binding-site similarities across non-homologous protein families that convergently evolved to bind similar ligands.
